TILIDIN AL COMP 100/8 - AN OVERVIEW

Soon after oral administration, tilidine is rapidly absorbed. It is actually matter to the pronounced first-pass effect. The conversion of tilidine to the greater potent active metabolite nortilidine occurs Along with the involvement of CYP3A4 and CYP2C19. Inhibition of such enzymes may thus alter the efficacy and tolerability profile of tilidine.E